tag:blogger.com,1999:blog-271453952024-03-08T01:15:33.039-08:00Future of the Pharma Industry and Health Care Trends - Keynote SpeakerTrends impacting the pharma industry including health care and biotech - by Dr Patrick Dixon - For his MAIN site (articles / free books / presentations / videos) see link on left - globalchange.com 10 million visitors)Patrick Dixonhttp://www.blogger.com/profile/09502347538023164141noreply@blogger.comBlogger51125tag:blogger.com,1999:blog-27145395.post-85485591332346082472017-12-13T11:24:00.002-08:002017-12-13T11:24:50.167-08:00How stem cells will regenerate your heart, liver, kidneys, eyes and brain - future health care trends<div dir="ltr" style="text-align: left;" trbidi="on">
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Every week we see more stories in the media about new ways to rebuild or repair damaged liver, heart, brain, spinal cord, eyes and so on.</div>
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What is the truth about this revolutionary technology? How much is really available now? When will organ regeneration become routine?</div>
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25 years ago I predicted the stem cell revolution, in one of my 16 books, The Genetic Revolution. Since then, I have worked with many of the world’s largest <a href="https://www.globalchange.com/index.php?option=com_content&view=article&id=110" style="color: #cc0000; font-weight: bold; margin: 0px; padding: 0px; text-decoration: none;">pharma</a> companies, helping them understand the future role of human <a href="https://www.globalchange.com/index.php?option=com_content&view=article&id=102" style="color: #cc0000; font-weight: bold; margin: 0px; padding: 0px; text-decoration: none;">stem cells</a> in organ repair and regeneration, as a physician and Futurist keynote speaker. </div>
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Here is the truth about <a href="https://www.globalchange.com/index.php?option=com_content&view=article&id=102" style="color: #cc0000; font-weight: bold; margin: 0px; padding: 0px; text-decoration: none;">stem cells</a> - with useful references below.</div>
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The key to all organ regeneration and repair is stem cells</h3>
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Stem cells are primitive cells which have the capacity to grow into many different types of organs.</div>
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We now know that whenever an organ in your body is injured, these special cells are released by the bone marrow into the blood, which automatically search out areas of damage. </div>
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The cells migrate to where they are most needed, and help in repairs. In most cases we think the way they do this is by producing special chemicals such as cytokines, and other proteins or fats, which stimulate local regeneration.</div>
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The good news is that doctors have decades of experience of using <a href="https://www.globalchange.com/index.php?option=com_content&view=article&id=102" style="color: #cc0000; font-weight: bold; margin: 0px; padding: 0px; text-decoration: none;">stem cells</a> in health care, treating people with advanced leukaemia which is <a href="https://www.globalchange.com/index.php?option=com_content&view=article&id=4403" style="color: #cc0000; font-weight: bold; margin: 0px; padding: 0px; text-decoration: none;">cancer</a> of the bone marrow. </div>
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And we can find <a href="https://www.globalchange.com/index.php?option=com_content&view=article&id=102" style="color: #cc0000; font-weight: bold; margin: 0px; padding: 0px; text-decoration: none;">stem cells</a> in many different parts of the body.</div>
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Over 1.5 million stem cell treatments already</h3>
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Over 1.5 million people with leukaemia had been treated with <a href="https://www.globalchange.com/index.php?option=com_content&view=article&id=102" style="color: #cc0000; font-weight: bold; margin: 0px; padding: 0px; text-decoration: none;">stem cells</a> by the end of 2017, in over 80 nations – with over 80,000 new treatments every year. </div>
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In 47% of cases, bone marrow is donated, usually by a close family member with the same tissue type (allogenic transplants).</div>
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53% have been treated with their own stem cells removed from their own body before treatment (autologous transplants).</div>
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<span lang="EN-US" style="margin: 0px; padding: 0px;">Cancer specialists routinely remove samples of bone marrow, separate out the <a href="https://www.globalchange.com/index.php?option=com_content&view=article&id=102" style="color: #cc0000; font-weight: bold; margin: 0px; padding: 0px; text-decoration: none;">stem cells</a> and store them, before giving someone a massive dose of radiation.<span mce_style="mso-spacerun:yes" style="margin: 0px; padding: 0px;"> </span></span></div>
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<span lang="EN-US" style="margin: 0px; padding: 0px;"><span mce_style="mso-spacerun:yes" style="margin: 0px; padding: 0px;"></span>As soon as it is complete, and all their bone marrow cells have died, they transplant healthy <a href="https://www.globalchange.com/index.php?option=com_content&view=article&id=102" style="color: #cc0000; font-weight: bold; margin: 0px; padding: 0px; text-decoration: none;">stem cells</a>back into their bone marrow.<span mce_style="mso-spacerun:yes" style="margin: 0px; padding: 0px;"> </span></span></div>
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<span lang="EN-US" style="margin: 0px; padding: 0px;"><span mce_style="mso-spacerun:yes" style="margin: 0px; padding: 0px;"></span>These divide rapidly, populating the entire bone marrow to regrow both red and white blood cells, and hopefully the person recovers. </span></div>
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<span lang="EN-US" style="margin: 0px; padding: 0px;">The major <a href="https://www.globalchange.com/index.php?option=com_content&view=article&id=4587" style="color: #cc0000; font-weight: bold; margin: 0px; padding: 0px; text-decoration: none;">risk</a> is temporary loss of immune system and becoming very ill from serious infections.</span></div>
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<span lang="EN-US" style="margin: 0px; padding: 0px;">Adult <a href="https://www.globalchange.com/index.php?option=com_content&view=article&id=102" style="color: #cc0000; margin: 0px; padding: 0px; text-decoration: none;">stem cells</a> can do everything we need - forget embryo stem cells</span></h3>
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Ten years or more ago, many so-called experts claimed that the only useful source of <a href="https://www.globalchange.com/index.php?option=com_content&view=article&id=102" style="color: #cc0000; font-weight: bold; margin: 0px; padding: 0px; text-decoration: none;">stem cells</a> for organ repair was human embryos. </div>
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The trouble is that using tissue from human embryos has huge <a href="https://www.globalchange.com/index.php?option=com_content&view=article&id=116" style="color: #cc0000; font-weight: bold; margin: 0px; padding: 0px; text-decoration: none;">ethical issues</a> for many people, including Christians, Muslims and Orthodox Jews. </div>
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For over 20 years, I have been saying that these experts were wrong. </div>
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It was obvious to me that we would be able to use adult stem cells, from the same body as someone needing treatment, and events have proved me correct.</div>
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So today for example, scientists are growing new retinal tissue to help blind people see, from skin cells.</div>
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Yes, that is correct. In every organ, including the brain, we can find immature cells, or stem cells, with varying degrees of specialization.</div>
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We can treat these same cells with chemicals to trick them into thinking that they are back in an embryo, or in a human foetus implanted into the womb. </div>
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A further step is to bath the cells with other chemical messengers, which make the cells think they are in a particular part of the body – the eye for example, and that they need to transform into retina, or cornea or whatever.</div>
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And scientists are getting superb results from these kinds of experiments.</div>
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So much so that very few stem cell researchers today are as excited as they were about using embryo cells. </div>
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For a start, such cells almost always risk being rejected as soon as they are transferred into a child or adult.</div>
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In contrast, when a person’s own cells are used to rebuild their own organs, by definition we have a perfect match.</div>
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How far can we go in organ regeneration and how do <a href="https://www.globalchange.com/index.php?option=com_content&view=article&id=102" style="color: #cc0000; margin: 0px; padding: 0px; text-decoration: none;">stem cells</a> really work?</h3>
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In both cases the answer is that we don’t yet know but results so far have been astonishing.</div>
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Take heart disease for example. For some years, doctors have been extracting stem cells from the bone marrow of heart patients, growing them in the lab and injecting them directly into heart muscle, or perfusing the arteries of the heart. </div>
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We know that some kinds of stem cells automatically migrate to areas of damaged tissue, where they settle down to help make a repair. This is a natural process and seems to go on inside our bodies every day.</div>
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There is a great debate between stem cell researchers about whether such <a href="https://www.globalchange.com/index.php?option=com_content&view=article&id=102" style="color: #cc0000; font-weight: bold; margin: 0px; padding: 0px; text-decoration: none;">stem cells</a> actually transform into useful heart muscle, or whether they just produce special proteins which aid repair. </div>
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Who knows, and really it does not matter. </div>
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The most important thing to understand is that heart function often improves. These stem cell treatments help the heart to recover normal strength in a way that feel near miraculous compared to heart treatments 20 years ago.</div>
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Can we do the same for the brain? </h3>
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The answer is almost certainly yes. In animal studies, scientists have been able to restore some brain function after stroke damage, or after other brain injuries, including chronic brain conditons, neurodegenerative diseases like Multiple Sclerosis or Motor Neurone Disease.</div>
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The brain has one very distinctive feature. Every blood vessel is lined by what we call the Blood Brain Barrier – designed to protect the brain from attack. </div>
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And this same barrier is an excellent screen against many of the white cells that patrol our bodies looking for foreign invaders such as bacteria or viruses. </div>
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But these same cells are the ones which can reject and destroy transplanted cells from other people.</div>
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What this means is that when it comes to brain repair, we are able to grow cell lines in the lab, from adult stem cells, which can in theory be injected into the brains of a large number of different people, without those cells being rejected.</div>
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Harvesting brain <a href="https://www.globalchange.com/index.php?option=com_content&view=article&id=102" style="color: #cc0000; margin: 0px; padding: 0px; text-decoration: none;">stem cells</a> from the olfactory bulb (nose)</h3>
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A good source of specialist <a href="https://www.globalchange.com/index.php?option=com_content&view=article&id=102" style="color: #cc0000; font-weight: bold; margin: 0px; padding: 0px; text-decoration: none;">stem cells</a> from the central nervous system is from the upper part of the nose. Right up near your frontal sinuses is a structure called the olfactory bulb. This is connected directly to your brain, through a tiny hold inside the skull. </div>
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The bulb is packed with nervous tissue, and is coated with cells which sense smell.</div>
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An easy way to harvest vast numbers of adult <a href="https://www.globalchange.com/index.php?option=com_content&view=article&id=102" style="color: #cc0000; font-weight: bold; margin: 0px; padding: 0px; text-decoration: none;">stem cells</a> suitable for the brain is to remove the olfactory bulb - although it means the person loses their ability to smell, which also impacts the way we "taste" food since most of the flavours we enjoy are actually sensed as aromas in the nose. </div>
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If you want proof of this, try eating some flavoursome food when holding your nose closed with your fingers.</div>
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Why stem cell trials are expanding so fast - lack of controls</h3>
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In hospitals all over the world, stem cell clinical trials are progressing rapidly – now researchers have realized they can abandon attempts to use embryo cells because adult <a href="https://www.globalchange.com/index.php?option=com_content&view=article&id=102" style="color: #cc0000; font-weight: bold; margin: 0px; padding: 0px; text-decoration: none;">stem cells</a> are a better alternative.</div>
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One reason why the research is developing so rapidly is that stem cell therapy bypasses almost all the steps needed in a normal $1 billion drug development process for a pharma company.</div>
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In drug trials, the first step is proving some kind of effect on human or animal tissue in a laboratory. The next step is animal studies for safety and impact. </div>
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After that comes Phase I clinical trials which are designed only to show the product is safe for use in humans. </div>
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Phase II clinical trials are small studies looking at impact on disease, followed by much larger Phase III trials, hopefully leading to strong evidence of benefit, and to a licence for sale.</div>
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But in the case of stem cells, there is no product to be tested. We are using living cells.</div>
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Stem cell research is not held back by normal drug trial regulations</h3>
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And because the cells themselves come from the person who is being treated, doctors don’t even need the normal permissions to carry out studies. Their <a href="https://www.globalchange.com/index.php?option=com_content&view=article&id=102" style="color: #cc0000; font-weight: bold; margin: 0px; padding: 0px; text-decoration: none;">stem cell research</a> cannot be regulated by normal drug development agencies.</div>
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After all, a patient can demand that cells removed earlier from their own body, are returned to their own body. </div>
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The cells belong to the patient so how can a regulatory authority insist that those <a href="https://www.globalchange.com/index.php?option=com_content&view=article&id=102" style="color: #cc0000; font-weight: bold; margin: 0px; padding: 0px; text-decoration: none;">stem cells</a> be thrown away?</div>
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If a sick person has been informed of all the risks of extracting, treating and processing some of their own cells before injecting them back inside their own bodies, then it can be argued that most of the <a href="https://www.globalchange.com/index.php?option=com_content&view=article&id=116" style="color: #cc0000; font-weight: bold; margin: 0px; padding: 0px; text-decoration: none;">ethical issues</a> have been dealt with.</div>
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Unregulated stem cell clinics springing up in many nations</h3>
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It also means that stem cell clinics are springing up all over the world, offering highly experimental treatments, often at high cost, often without rigorous scientific data published in respected research journals, proving that their methods actually work.</div>
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Just one example is a doctor who has been injecting bone marrow <a href="https://www.globalchange.com/index.php?option=com_content&view=article&id=102" style="color: #cc0000; font-weight: bold; margin: 0px; padding: 0px; text-decoration: none;">stem cells</a> into eyes of people who are blind, claiming that many patients have had partially restored sight as a result. </div>
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<span lang="EN-US" style="margin: 0px; padding: 0px;">In the meantime, a large number of animal studies using <a href="https://www.globalchange.com/index.php?option=com_content&view=article&id=102" style="color: #cc0000; font-weight: bold; margin: 0px; padding: 0px; text-decoration: none;">stem cells</a> are also showing benefit – for example for retinal repair.<span mce_style="mso-spacerun:yes" style="margin: 0px; padding: 0px;"> </span><o:p style="margin: 0px; padding: 0px;"></o:p></span></div>
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Here are some examples of stem cell results in humans</h3>
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<b style="margin: 0px; padding: 0px;">Brain</b></div>
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Stem cells are being injected into the brains of people with Parkinsons Disease, who are lacking in brain cells which produce dopamine. </div>
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The work is in early stages and there are of course concerns that such cells might go on dividing too rapidly, creating some kind of brain tumours. </div>
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But first studies seem to show reduction in symptoms in some patients. </div>
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As is the case with repair of heart muscle using stem cells, we are uncertain about how these cells benefit brain function. The answer is likely to be a combination of neurogenesis (formation of new nerve cells), generation of new blood vessels, and release of proteins of various kinds which assist existing cells within the brain to recover and repair the damage.</div>
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Up to 10 million mesenchymal stem cells from bone marrow have been injected into patients with stroke, through holes in the skull, with what appears to be positive results. </div>
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It is hard to be certain because people with stroke tend to see improvements as part of normal recovery, but their doctors reported unexpected gains in movement and speech capability. </div>
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We know from studies in rats that these bone marrow <a href="https://www.globalchange.com/index.php?option=com_content&view=article&id=102" style="color: #cc0000; font-weight: bold; margin: 0px; padding: 0px; text-decoration: none;">stem cells</a> do not survive in the brain for long, but they produce large amounts of special proteins which stimulate natural brain repair and growth mechanisms.</div>
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<span lang="EN-US" style="margin: 0px; padding: 0px;"><b style="margin: 0px; padding: 0px;">Liver</b></span></div>
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<span lang="EN-US" style="margin: 0px; padding: 0px;">Stem cells are being explored as a therapy for liver cirrhosis.<span mce_style="mso-spacerun:yes" style="margin: 0px; padding: 0px;"> </span>Good results have been seen in animal studies. https://www.medicalnewstoday.com/articles/297102.php</span></div>
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<span lang="EN-US" style="margin: 0px; padding: 0px;"><b style="margin: 0px; padding: 0px;">Spinal cord</b></span></div>
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<span lang="EN-US" style="margin: 0px; padding: 0px;">Spinal cord damage is complicated because of a glue that that the body makes in response to spinal injury. </span></div>
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<span lang="EN-US" style="margin: 0px; padding: 0px;">This glue is a terrible problem because it tangles up the ends of broken nerves as they begin to regrow.<span mce_style="mso-spacerun:yes" style="margin: 0px; padding: 0px;"> </span>If you cut a peripheral nerve in your hand or arm for example, it is not long before the neurons begin to grow again, creeping their way down the old nerve sheath so long as it is carefully stitched back into place.<span mce_style="mso-spacerun:yes" style="margin: 0px; padding: 0px;"> </span></span></div>
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<span lang="EN-US" style="margin: 0px; padding: 0px;"><span mce_style="mso-spacerun:yes" style="margin: 0px; padding: 0px;"></span>Nerves grow at around 3mm a day, so the recovery is significant in many cases.<span mce_style="mso-spacerun:yes" style="margin: 0px; padding: 0px;"> </span>And exactly the same could happen in theory after a big spinal injury.<span mce_style="mso-spacerun:yes" style="margin: 0px; padding: 0px;"> </span>So <a href="https://www.globalchange.com/index.php?option=com_content&view=article&id=102" style="color: #cc0000; font-weight: bold; margin: 0px; padding: 0px; text-decoration: none;">stem cells</a> are being used to try and restore the normal <a href="https://www.globalchange.com/index.php?option=com_content&view=article&id=170" style="color: #cc0000; font-weight: bold; margin: 0px; padding: 0px; text-decoration: none;">environment</a> in the damaged area of the spine, with some success.</span></div>
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<span lang="EN-US" style="margin: 0px; padding: 0px;"><b style="margin: 0px; padding: 0px;">Retina</b></span></div>
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<span lang="EN-US" style="margin: 0px; padding: 0px;">As I said above, many different methods are being used to help restore sight in people who are blind.<span mce_style="mso-spacerun:yes" style="margin: 0px; padding: 0px;"> </span></span></div>
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<span lang="EN-US" style="margin: 0px; padding: 0px;"><span mce_style="mso-spacerun:yes" style="margin: 0px; padding: 0px;"></span>In one technique, skin cells have been used to grow sheets of light sensitive retinal cells.<span mce_style="mso-spacerun:yes" style="margin: 0px; padding: 0px;"> </span>These are inserted through a small cut in the eyeball, and placed onto the surface of the back of the eye, glued into location by lasers.<span mce_style="mso-spacerun:yes" style="margin: 0px; padding: 0px;"> </span></span></div>
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<span lang="EN-US" style="margin: 0px; padding: 0px;"><span mce_style="mso-spacerun:yes" style="margin: 0px; padding: 0px;"></span>After a few weeks, some of those cells, in some people treated, have become established and connected up to the optic nerve.<span mce_style="mso-spacerun:yes" style="margin: 0px; padding: 0px;"> </span>This is a treatment for people with macular degeneration.<o:p style="margin: 0px; padding: 0px;"></o:p></span></div>
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<b style="margin: 0px; padding: 0px;">Pancreas</b></div>
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Stem cells have been used to create new insulin secreting cells. </div>
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When they are injected back into the pancreas of someone with Type I diabetes, it is not long befire their immune system destroys them in a repeat of slywhat happened previously. So researchers came up with an ingenious plan. </div>
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They created a plastic-type membrane as a bag, which has holes large enough to allow nutrients such as sugar and amino acids in to feed the insulin cells, but small enough to prevent those cells escaping, and to prevent white soldier cells from entering to attack. </div>
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When these bags are placed inside the body, the person is able to make pure human insulin again. </div>
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<span lang="EN-US" style="margin: 0px; padding: 0px;"><b style="margin: 0px; padding: 0px;">Regrowing fingers, toes, arms or legs</b><o:p style="margin: 0px; padding: 0px;"></o:p></span></div>
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1.5 million people in America alone are missing one or more limbs. </div>
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Newts are well known for their ability to regrow a lost tail. And other species are also able to regenerate severed limbs. </div>
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Stem cells have now been used to grow a new limb for rats. The technique is complicated, and involves preparing a scaffold onto which new <a href="https://www.globalchange.com/index.php?option=com_content&view=article&id=102" style="color: #cc0000; font-weight: bold; margin: 0px; padding: 0px; text-decoration: none;">stem cells</a> can become attached to form new tissues. </div>
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The scaffold is made from the corresponding limb of a dead animal, with cells dissolved away, leaving the extra-cellular matrix, including the sheaths of nerves. The new limb has then been successfully attached to a live animal. A similar process has been used to grow artificial kidneys, bladders and so on.</div>
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Drugs which tell your own <a href="https://www.globalchange.com/index.php?option=com_content&view=article&id=102" style="color: #cc0000; margin: 0px; padding: 0px; text-decoration: none;">stem cells</a> to repair your organs </h3>
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<span lang="EN-US" style="margin: 0px; padding: 0px;">Once we recognize the extraordinary fact that your own bone marrow has the ability to help repair organs around the body, it raises a very important possibility.<o:p style="margin: 0px; padding: 0px;"></o:p></span></div>
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Back in 2003, I predicted that we would one day be able to give sick people a couple of injections to prepare the body and then trigger release of tens of millions of their own <a href="https://www.globalchange.com/index.php?option=com_content&view=article&id=102" style="color: #cc0000; font-weight: bold; margin: 0px; padding: 0px; text-decoration: none;">stem cells</a> from their bone marrow.<span mce_style="mso-spacerun:yes" style="margin: 0px; padding: 0px;"> </span>We are now very close to seeing this as a routine treatment.<span mce_style="mso-spacerun:yes" style="margin: 0px; padding: 0px;"> </span></div>
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This is really important.<span mce_style="mso-spacerun:yes" style="margin: 0px; padding: 0px;"> </span>If it works well, it would mean that we don’t need any longer to go to all the trouble to extract stem cells, treat them, grow them and inject them back.<span mce_style="mso-spacerun:yes" style="margin: 0px; padding: 0px;"> </span></div>
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<span mce_style="mso-spacerun:yes" style="margin: 0px; padding: 0px;"></span>And it also means that for the first time, <a href="https://www.globalchange.com/index.php?option=com_content&view=article&id=110" style="color: #cc0000; font-weight: bold; margin: 0px; padding: 0px; text-decoration: none;">pharma</a> companies can enter the stem cell revolution.</div>
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The trouble about stem cell therapy from the <a href="https://www.globalchange.com/index.php?option=com_content&view=article&id=110" style="color: #cc0000; font-weight: bold; margin: 0px; padding: 0px; text-decoration: none;">pharma</a> compay point of view is that there is no actual product.<span mce_style="mso-spacerun:yes" style="margin: 0px; padding: 0px;"> </span>The only thing we are giving the patient is their own cells.<span mce_style="mso-spacerun:yes" style="margin: 0px; padding: 0px;"> </span>The only commercial benefits therefore are for companies selling equipment to extract stem cells, protect and grow them in the laboratory and so on. </div>
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<span lang="EN-US" style="margin: 0px; padding: 0px;">Risks of stem cell therapy</span></h3>
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All experimental treatments carry risks of various kinds.<span mce_style="mso-spacerun:yes" style="margin: 0px; padding: 0px;"> </span></div>
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<span mce_style="mso-spacerun:yes" style="margin: 0px; padding: 0px;"></span>In the case of stem cells, they can be split into mechanical risks, for example from injecting directly through the skull and into the brain, and cellular risks, for example that these cells might become out of control and cancerous.</div>
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<b style="margin: 0px; padding: 0px;">Here are some <a href="https://www.globalchange.com/index.php?option=com_content&view=article&id=102" style="color: #cc0000; margin: 0px; padding: 0px; text-decoration: none;">stem cell research</a> links on which some of the above was based:</b></div>
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<span lang="EN-US" style="margin: 0px; padding: 0px;">https://www.nature.com/articles/bmt201618</span></div>
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<span lang="EN-US" style="margin: 0px; padding: 0px;"></span></div>
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https://www.sciencealert.com/a-blind-woman-has-regained-sight-thanks-to-a-controversial-stem-cell-treatment</div>
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https://www.newscientist.com/article/2091841-stem-cell-brain-injections-let-people-walk-again-after-stroke/</div>
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<span lang="EN-US" style="margin: 0px; padding: 0px;">https://www.medicalnewstoday.com/articles/294850.php</span></div>
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<span lang="EN-US" style="margin: 0px; padding: 0px;">https://www.sciencedaily.com/releases/2017/01/170110120709.htm</span></div>
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<span lang="EN-US" style="margin: 0px; padding: 0px;">https://www.theguardian.com/science/2009/jan/08/stem-cells-bone-marrow-heart-attack</span></div>
</div>
Patrick Dixonhttp://www.blogger.com/profile/09502347538023164141noreply@blogger.com0tag:blogger.com,1999:blog-27145395.post-9892586931383717652014-10-29T02:07:00.007-07:002014-10-29T02:07:23.940-07:00Future of Health Care and Medical Technology - keynote speaker Patrick D...<iframe allowfullscreen="" frameborder="0" height="270" src="https://www.youtube.com/embed/VarFyhtta2o" width="480"></iframe>Patrick Dixonhttp://www.blogger.com/profile/09502347538023164141noreply@blogger.com0tag:blogger.com,1999:blog-27145395.post-80836186462574809422014-10-29T02:07:00.005-07:002014-10-29T02:07:22.711-07:00Future of Health Care and Medical Technology - keynote speaker Patrick D...<iframe allowfullscreen="" frameborder="0" height="270" src="https://www.youtube.com/embed/VarFyhtta2o" width="480"></iframe>Patrick Dixonhttp://www.blogger.com/profile/09502347538023164141noreply@blogger.com0tag:blogger.com,1999:blog-27145395.post-33939586839601757362014-10-29T02:07:00.003-07:002014-10-29T02:07:21.979-07:00Future of Health Care and Medical Technology - keynote speaker Patrick D...<iframe allowfullscreen="" frameborder="0" height="270" src="https://www.youtube.com/embed/VarFyhtta2o" width="480"></iframe>Patrick Dixonhttp://www.blogger.com/profile/09502347538023164141noreply@blogger.com0tag:blogger.com,1999:blog-27145395.post-85768381539593012352014-10-29T02:07:00.001-07:002014-10-29T02:07:21.373-07:00Future of Health Care and Medical Technology - keynote speaker Patrick D...<iframe allowfullscreen="" frameborder="0" height="270" src="https://www.youtube.com/embed/VarFyhtta2o" width="480"></iframe>Patrick Dixonhttp://www.blogger.com/profile/09502347538023164141noreply@blogger.com0tag:blogger.com,1999:blog-27145395.post-25824572335713499852014-02-28T03:32:00.001-08:002014-02-28T03:32:07.389-08:00Computers smarter than Physicians? Future Health Care / Med Tech trends ...<iframe allowfullscreen="" frameborder="0" height="270" src="//www.youtube.com/embed/HA1QAfhZrSw" width="480"></iframe>Patrick Dixonhttp://www.blogger.com/profile/09502347538023164141noreply@blogger.com0tag:blogger.com,1999:blog-27145395.post-85279559392711146332014-02-24T23:21:00.001-08:002014-02-24T23:21:28.869-08:00How To Prevent Ageing - Stay Young Forever - Future Pharma Health Care ...<iframe allowfullscreen="" frameborder="0" height="270" src="//www.youtube.com/embed/f-Q2xIuL73Q" width="480"></iframe>Patrick Dixonhttp://www.blogger.com/profile/09502347538023164141noreply@blogger.com0tag:blogger.com,1999:blog-27145395.post-41313062034314915972014-02-15T02:34:00.001-08:002014-02-15T02:34:36.029-08:00Big Data in Health Care - Information Overload, self-service health care...<iframe allowfullscreen="" frameborder="0" height="270" src="//www.youtube.com/embed/KteDr5HnNGY" width="480"></iframe>Patrick Dixonhttp://www.blogger.com/profile/09502347538023164141noreply@blogger.com0tag:blogger.com,1999:blog-27145395.post-73714159856513805382014-02-14T13:25:00.001-08:002014-02-14T13:25:27.170-08:00Why future of MedTech, global economy etc will be driven by emotion - Fu...<iframe allowfullscreen="" frameborder="0" height="270" src="//www.youtube.com/embed/ahcAFnY6iAY" width="480"></iframe>Patrick Dixonhttp://www.blogger.com/profile/09502347538023164141noreply@blogger.com0tag:blogger.com,1999:blog-27145395.post-82986864314989779172013-01-31T09:52:00.001-08:002013-01-31T09:52:51.962-08:00Micro-dose chemo for cancer using oncolytic viruses. Cancer therapy - fu...<iframe allowfullscreen="" frameborder="0" height="270" src="http://www.youtube.com/embed/Y3VneIw5dBo" width="480"></iframe>Patrick Dixonhttp://www.blogger.com/profile/09502347538023164141noreply@blogger.com0tag:blogger.com,1999:blog-27145395.post-37539974947115249902013-01-31T08:22:00.001-08:002013-01-31T08:22:08.831-08:00Micro-dose radiation using oncolytic viruses. How oncolytic viruses kill...<iframe allowfullscreen="" frameborder="0" height="270" src="http://www.youtube.com/embed/5vDVYFCF8S8" width="480"></iframe>Patrick Dixonhttp://www.blogger.com/profile/09502347538023164141noreply@blogger.com0tag:blogger.com,1999:blog-27145395.post-49461923711706875122013-01-30T15:34:00.001-08:002013-01-30T15:34:05.205-08:00Oncolytic viruses kill cancer cells: oncolytic virus research. Future he...<iframe allowfullscreen="" frameborder="0" height="270" src="http://www.youtube.com/embed/DsPN7G1VDRE" width="480"></iframe>Patrick Dixonhttp://www.blogger.com/profile/09502347538023164141noreply@blogger.com0tag:blogger.com,1999:blog-27145395.post-20619583927075625722012-12-23T11:13:00.001-08:002012-12-23T11:13:56.229-08:00How Oncolytic Viruses Kill Cancer Cells: research, trials, cancer treatm...<iframe allowfullscreen="" frameborder="0" height="270" src="http://www.youtube.com/embed/gFol3Cm9CAM" width="480"></iframe> <style>
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<div class="MsoNormal"><span lang="EN-US">How Oncolytic Viruses Kill Cancer Cells: research, clinical trials, cancer treatment, possible cure for cancer</span></div><div class="MsoNormal"><br />
</div><div class="MsoNormal"><span lang="EN-US">More: <a href="http://www.virttu.com/">http://www.virttu.com</a> .<span style="mso-spacerun: yes;"> </span>How oncolytic viruses work to kill cancer cells in melanoma, head and neck, prostate cancer and glioblastoma brain timours. Replication of oncolytic viruses inside tumours. Pre-clinical trials. Phase I, Phase II and Phase III clinical trials on oncolytics.<span style="mso-spacerun: yes;"> </span>Use of oncolytic viruses to treat advanced malignant melanoma and mestatases – Amgen research using an oncolytic virus developed from HSV (Herpes Simplex Virus).<span style="mso-spacerun: yes;"> </span>Problems with traditional chemotherapy – side effects.<span style="mso-spacerun: yes;"> </span>Why Amgen bought an oncolytic viruse for $500m in cash and $500m to be paid if oncolytic trials are fully successful. Investor interest in oncolytic viruses.<span style="mso-spacerun: yes;"> </span>Lessons from the history of research and development in monoclonal antibodies in cancer treatment. Why targeted cancer therapy – a so-called “magic bullet” is so needed.<span style="mso-spacerun: yes;"> </span>How oncolytic viruses have been modified so that they cannot replicate in normal cells, but are still able to divide in a wide variety of human cancer cells. History of oncolytic viruses.<span style="mso-spacerun: yes;"> </span>Arming oncolytic viruses. Using viruses like Seprehvir (HSV-1716), adapted to carry an additional payload: extra genes which teach infected cancer cells to take up a compound containing radioactive iodine from the blood, delivering a micro-dose of radiation inside individual cancer calls.<span style="mso-spacerun: yes;"> </span>Or adding a gene which teaches cancer cells how to split a harmless pro-drug into two, inside the cell, releasing a very toxic chemo (alkylating agent).<span style="mso-spacerun: yes;"> </span>Targetting oncolytic viruses – by adapting the feet of a virus to that they latch onto receptors on the surface of specific human cancer cells such as prostate.<span style="mso-spacerun: yes;"> </span>Results of early Phase III Rheolysin clinical trials – combined oncolytic virus and cancer chemotherapy. Side effects and safety profile of oncolytic viruses in clinical studies.<span style="mso-spacerun: yes;"> </span>FDA safety review of oncolytic viruses and approval for systemic administration of oncolytic viruses to children with advanced cancer. How genes work in viruses, and how genetic engineering allows us to cut and paste genes from one species into another. Patrick Dixon author of The Genetic Revolution, Chairman of Global Change Ltd, an advisor to many large pharma companies and to Virttu Biologics Ltd.</span></div>Patrick Dixonhttp://www.blogger.com/profile/09502347538023164141noreply@blogger.com0tag:blogger.com,1999:blog-27145395.post-34223039052367843252012-03-20T04:49:00.003-07:002012-03-20T04:49:43.628-07:00From Sick to Super-Human - future of pharmaceutical industry and health ...<iframe allowfullscreen="" frameborder="0" height="270" src="http://www.youtube.com/embed/bktRwIN68rM?fs=1" width="480"></iframe>Patrick Dixonhttp://www.blogger.com/profile/09502347538023164141noreply@blogger.com0tag:blogger.com,1999:blog-27145395.post-1423541084481175742012-03-20T04:49:00.001-07:002012-03-20T04:49:06.116-07:00How to Predict Sickness: gene prophecy - future of pharmaceutical indust...<iframe allowfullscreen="" frameborder="0" height="270" src="http://www.youtube.com/embed/EFjhKS7bPrE?fs=1" width="480"></iframe>Patrick Dixonhttp://www.blogger.com/profile/09502347538023164141noreply@blogger.com0tag:blogger.com,1999:blog-27145395.post-6458556852616016132012-03-20T04:47:00.001-07:002012-03-20T04:47:06.482-07:00Stop getting old - animals that don't age - future health care - confere...<iframe allowfullscreen="" frameborder="0" height="270" src="http://www.youtube.com/embed/VSXLICjh0K0?fs=1" width="480"></iframe>Patrick Dixonhttp://www.blogger.com/profile/09502347538023164141noreply@blogger.com0tag:blogger.com,1999:blog-27145395.post-29023727148495277802012-03-20T04:46:00.003-07:002012-03-20T04:46:40.687-07:00Stop Getting Old! Impact on you, family, wider world. Future pharmaceuti...<iframe allowfullscreen="" frameborder="0" height="270" src="http://www.youtube.com/embed/gB7vFuKd96Q?fs=1" width="480"></iframe>Patrick Dixonhttp://www.blogger.com/profile/09502347538023164141noreply@blogger.com0tag:blogger.com,1999:blog-27145395.post-47946793563571735592012-03-20T04:46:00.001-07:002012-03-20T04:46:13.743-07:00Health Care - Good and Bad - why it matters to me - motivational confere...<iframe allowfullscreen="" frameborder="0" height="270" src="http://www.youtube.com/embed/k23qvCQl9hQ?fs=1" width="480"></iframe>Patrick Dixonhttp://www.blogger.com/profile/09502347538023164141noreply@blogger.com0tag:blogger.com,1999:blog-27145395.post-91664724895759777802011-11-05T05:56:00.000-07:002011-11-05T05:56:57.250-07:00Rejuvenation therapy - revitalize, renew, stop ageing, getting old - lat...<iframe src="http://www.youtube.com/embed/zQiIJiLd_E0?fs=1" allowfullscreen="" frameborder="0" height="270" width="480"></iframe><br /><br />How scientists are discovering the secrets of eternal youth in animals -- and potentially in humans. How to stop getting old, turning off the normal physiology of ageing processes in human cells. Lessons from whales, rockfish project, turtles and parrots as well as other animals with longer lifespan. Impact on future life expectancy -- life insurance, pensions, unfunded pension liabilities, annuity rates, government debts, corporate pension fund valuations. Conference keynote speaker Patrick Dixon.Patrick Dixonhttp://www.blogger.com/profile/09502347538023164141noreply@blogger.com0tag:blogger.com,1999:blog-27145395.post-34611798403446393772011-07-21T12:25:00.000-07:002011-07-21T12:25:24.224-07:00Here Comes Radical Change: Future of Public Services, Demographics -- Ke...<iframe src="http://www.youtube.com/embed/XAa-0tiro-E?fs=1" allowfullscreen="" frameborder="0" height="295" width="480"></iframe><br /><br />Patrick Dixon -- conference keynote speaker -- impact of demographics, birth rates, youth, urban migration and immigration, life expectancy forecasts. All impact demand for public services, health care budgets, community services, demand for education, need for schools. Presentation for Welsh Parliament to public sector workers -- police officers, fire service, local councils, municipal authorities, teachers, social workers, health visitors, care assistants, community officers, health and safety advisors, government contractors and service providers. Changing culture, challenging structures and attitudes. Practical leadership lessons in change management for public sector workers. Team leadership and motivation to change working practices, encourage efficiency, cost savings, better standards, improved output and service impact.Patrick Dixonhttp://www.blogger.com/profile/09502347538023164141noreply@blogger.com0tag:blogger.com,1999:blog-27145395.post-88599884883960884612011-06-28T12:50:00.000-07:002011-06-28T12:50:58.923-07:00Stop Getting Older - Anti-ageing research - stay young. Future Health -...<iframe src="http://www.youtube.com/embed/dJtVxwhGOfs?fs=1" allowfullscreen="" width="480" frameborder="0" height="295"></iframe><br /><br />Antiageing therapies, science and research -- how to stop your biological clock. 65% of health care spending on people over 65 years old. Aging process -- physiology of aging and remedies, antiaging therapies. How to stay young. 7 key mechanisms of ageing in human cells. How we share common aging processes with many other animals. Shared genetic code and cell structures. Non-aging fish and whales. Genetic basis of ageing and aging as a treatable condition. Genetic damage inside nucleus of cell, damage to mitochondrial DNA. From health to performance, from sickness to wellness. Better memory, more energy, better sexual performance - Future of health care. Patrick Dixon is a health care keynote speaker at many health conferences. How patients, clients, over the counter therapy customers, and consumers of health care products will manage their own treatment. Patient choice and public health policy changes with government budget health cuts, health care rationing, post code lotteries. Private and public funding for health care treatment. How doctors and nurses will manage patients who often know more about their own medical condition, have made their own diagnosis, have made decisions about their own treatment (patient autonomy). Impact on over the counter pharmaceutical industry, chemists, drug stores, pharmacies and retail sales of health related products. Wellbeing, disease prevention, health promotion, vitamin and health supplements, dietary supplements. Future of the pharmaceutical industry with non-prescription medicines, remedies, therapies, drugs. Prescribing new treatments using new diagnostic tools, and patient clinical care pathways. Health policy development by governments, and health insurance companies. Patient survival and increase in life expectancy with early diagnosis and treatment using equipment bought by consumers for home use. Future of the NHS and national health service, medicare in America. Funding of health care in future -- people expected to fund their own health needs.Patrick Dixonhttp://www.blogger.com/profile/09502347538023164141noreply@blogger.com0tag:blogger.com,1999:blog-27145395.post-9696130733373567532011-06-28T09:25:00.000-07:002011-06-28T09:25:18.239-07:00Stop getting old - science of ageing - how to stay young. Health keynot...<iframe src="http://www.youtube.com/embed/2Wvcz64T9DM?fs=1" allowfullscreen="" frameborder="0" height="295" width="480"></iframe><br /><br />Mitochondria research -- improving memory, energy levels, use of food to create power inside cells. Antiageing therapies, science and research -- how to stop your biological clock. 65% of health care spending on people over 65 years old. Aging process -- physiology of aging and remedies, antiaging therapies. How to stay young. 7 key mechanisms of ageing in human cells. How we share common aging processes with many other animals. Shared genetic code and cell structures. Non-aging fish and whales. Genetic basis of ageing and aging as a treatable condition. Genetic damage inside nucleus of cell, damage to mitochondrial DNA. From health to performance, from sickness to wellness. Better memory, more energy, better sexual performance - Future of health care. Patrick Dixon is a health care keynote speaker at many health conferences. How patients, clients, over the counter therapy customers, and consumers of health care products will manage their own treatment. Patient choice and public health policy changes with government budget health cuts, health care rationing, post code lotteries. Private and public funding for health care treatment. How doctors and nurses will manage patients who often know more about their own medical condition, have made their own diagnosis, have made decisions about their own treatment (patient autonomy). Impact on over the counter pharmaceutical industry, chemists, drug stores, pharmacies and retail sales of health related products. Wellbeing, disease prevention, health promotion, vitamin and health supplements, dietary supplements. Future of the pharmaceutical industry with non-prescription medicines, remedies, therapies, drugs. Prescribing new treatments using new diagnostic tools, and patient clinical care pathways. Health policy development by governments, and health insurance companies. Patient survival and increase in life expectancy with early diagnosis and treatment using equipment bought by consumers for home use. Future of the NHS and national health service, medicare in America. Funding of health care in future -- people expected to fund their own health needs.Patrick Dixonhttp://www.blogger.com/profile/09502347538023164141noreply@blogger.com0tag:blogger.com,1999:blog-27145395.post-49901242808675078902011-06-28T06:50:00.000-07:002011-06-28T06:50:56.023-07:00Alternative Therapies and Treatments - Physicians and Pharmaceutical Ind...<iframe src="http://www.youtube.com/embed/YqgU5CJRqBg?fs=1" allowfullscreen="" frameborder="0" height="295" width="480"></iframe><br /><br />Alternative medicine, therapies, homeopathy, chiropractice, Antiageing therapies, science and research -- how to stop your biological clock. unmet medical needs. Traditional healers and herbal remedies. 65% of health care spending on people over 65 years old. Aging process -- physiology of aging and remedies, antiaging therapies. How to stay young. 7 key mechanisms of ageing in human cells. How we share common aging processes with many other animals. Shared genetic code and cell structures. Non-aging fish and whales. Genetic basis of ageing and aging as a treatable condition. Genetic damage inside nucleus of cell, damage to mitochondrial DNA. From health to performance, from sickness to wellness. Better memory, more energy, better sexual performance - Future of health care. Patrick Dixon is a health care keynote speaker at many health conferences. How patients, clients, over the counter therapy customers, and consumers of health care products will manage their own treatment. Patient choice and public health policy changes with government budget health cuts, health care rationing, post code lotteries. Private and public funding for health care treatment. How doctors and nurses will manage patients who often know more about their own medical condition, have made their own diagnosis, have made decisions about their own treatment (patient autonomy). Impact on over the counter pharmaceutical industry, chemists, drug stores, pharmacies and retail sales of health related products. Wellbeing, disease prevention, health promotion, vitamin and health supplements, dietary supplements. Future of the pharmaceutical industry with non-prescription medicines, remedies, therapies, drugs. Prescribing new treatments using new diagnostic tools, and patient clinical care pathways. Health policy development by governments, and health insurance companies. Patient survival and increase in life expectancy with early diagnosis and treatment using equipment bought by consumers for home use. Future of the NHS and national health service, medicare in America. Funding of health care in future -- people expected to fund their own health needs.Patrick Dixonhttp://www.blogger.com/profile/09502347538023164141noreply@blogger.com0tag:blogger.com,1999:blog-27145395.post-88339695346364402962011-06-28T06:28:00.000-07:002011-06-28T06:28:07.506-07:00Get More Energy! Treatment for tiredeness, fatigue: Mitochondria researc...<iframe src="http://www.youtube.com/embed/iBZeoO9DooI?fs=1" allowfullscreen="" frameborder="0" height="295" width="480"></iframe><br /><br />Mitochondria research – improving memory, energy levels, use of food to create power inside cells. Treatments for chronic tiredeness and chronic fatigue syndrome. Antiageing therapies, science and research – how to stop your biological clock. 65% of health care spending on people over 65 years old. Aging process – physiology of aging and remedies, antiaging therapies. How to stay young. 7 key mechanisms of ageing in human cells. How we share common aging processes with many other animals. Shared genetic code and cell structures. Non-aging fish and whales. Genetic basis of ageing and aging as a treatable condition. Genetic damage inside nucleus of cell, damage to mitochondrial DNA. From health to performance, from sickness to wellness. Better memory, more energy, better sexual performance - Future of health care. Patrick Dixon is a health care keynote speaker at many health conferences. How patients, clients, over the counter therapy customers, and consumers of health care products will manage their own treatment. Patient choice and public health policy changes with government budget health cuts, health care rationing, post code lotteries. Private and public funding for health care treatment. How doctors and nurses will manage patients who often know more about their own medical condition, have made their own diagnosis, have made decisions about their own treatment (patient autonomy). Impact on over the counter pharmaceutical industry, chemists, drug stores, pharmacies and retail sales of health related products. Wellbeing, disease prevention, health promotion, vitamin and health supplements, dietary supplements. Future of the pharmaceutical industry with non-prescription medicines, remedies, therapies, drugs. Prescribing new treatments using new diagnostic tools, and patient clinical care pathways. Health policy development by governments, and health insurance companies. Patient survival and increase in life expectancy with early diagnosis and treatment using equipment bought by consumers for home use. Future of the NHS and national health service, medicare in America. Funding of health care in future – people expected to fund their own health needs.Patrick Dixonhttp://www.blogger.com/profile/09502347538023164141noreply@blogger.com0tag:blogger.com,1999:blog-27145395.post-13764208427283063112011-06-28T06:15:00.000-07:002011-06-28T06:15:58.901-07:00Ageing nations - social and health impact of demographics - economy and ...<iframe src="http://www.youtube.com/embed/b2rGKpjID_4?fs=1" allowfullscreen="" frameborder="0" height="295" width="480"></iframe><br /><br />Ageing population, demographics, balance in age groups, birth rates and death rates. Population growth and decline. Baby boomers and baby boom. Migration and immigration patterns and public policies. Antiageing therapies, science and research -- how to stop your biological clock. 65% of health care spending on people over 65 years old. Aging process -- physiology of aging and remedies, antiaging therapies. How to stay young. 7 key mechanisms of ageing in human cells. How we share common aging processes with many other animals. Shared genetic code and cell structures. Non-aging fish and whales. Genetic basis of ageing and aging as a treatable condition. Genetic damage inside nucleus of cell, damage to mitochondrial DNA. From health to performance, from sickness to wellness. Better memory, more energy, better sexual performance - Future of health care. Patrick Dixon is a health care keynote speaker at many health conferences. How patients, clients, over the counter therapy customers, and consumers of health care products will manage their own treatment. Patient choice and public health policy changes with government budget health cuts, health care rationing, post code lotteries. Private and public funding for health care treatment. How doctors and nurses will manage patients who often know more about their own medical condition, have made their own diagnosis, have made decisions about their own treatment (patient autonomy). Impact on over the counter pharmaceutical industry, chemists, drug stores, pharmacies and retail sales of health related products. Wellbeing, disease prevention, health promotion, vitamin and health supplements, dietary supplements. Future of the pharmaceutical industry with non-prescription medicines, remedies, therapies, drugs. Prescribing new treatments using new diagnostic tools, and patient clinical care pathways. Health policy development by governments, and health insurance companies. Patient survival and increase in life expectancy with early diagnosis and treatment using equipment bought by consumers for home use. Future of the NHS and national health service, medicare in America. Funding of health care in future -- people expected to fund their own health needs.Patrick Dixonhttp://www.blogger.com/profile/09502347538023164141noreply@blogger.com0